TRAF4 CLIA Kit for Human(Homo sapiens) | EIAab.comTRAF4 CLIA Kit for Human(Homo sapiens)

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Index > Protein center > TRAF4(Gene name) > Human

TRAF4 (Gene name),

TNF receptor-associated factor 4 (Protein name ), TRAF4_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

TRAF4(CART1;MLN62;RNF83);

Protein name:

TNF receptor-associated factor 4;

Alternative:

Metastatic lymph node gene 62 protein(MLN 62);Cysteine-rich domain associated with RING and Traf domains protein 1;RING finger protein 83;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homotrimer (Probable). Interacts with LTBR/TNFRSF3, NGFR/TNFRSF16, RPS6KB1 and TGFB1I1. Interacts with SMURF1. Interacts (via TRAF domain) with MAP3K4 (via kinase domain). Interacts with NCF1, TICAM1, IRAK1 and TRAF6, and is probably part of a complex containing TRAF4, NCF1, TICAM1, IRAK1 and TRAF6.

Function:

Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions.

Subcellular Location:

Cytoplasm Nucleus Cytoplasm perinuclear region Cell junction tight junction Cell membrane Peripheral membrane protein Cytoplasmic side Cytoplasm cytoskeleton

Protein Attributes:

Sequence length:

470

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

470:

VRDDAVFIRA | AVELPRKILS |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q9BUZ4

STRING:

9606.ENSP00000262395

KEGG:

hsa:9618

MIM:

602464

Pfam:

PF00917

UniGene:

Hs.8375

String:

Q9BUZ4

Uniprot:

Q9BUZ4

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ELISA Kit for Human TNF receptor-associated factor 4

Cat.:

E15310h

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96T

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ELISA Kit for Human TNF receptor-associated factor 4

Cat.:

E15310m

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MSDS:

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Packing:

96T

CLIA Kit for Human TNF receptor-associated factor 4

Cat.:

U15310h

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MSDS:

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Packing:

96T

CLIA Kit for Human TNF receptor-associated factor 4

Cat.:

U15310m

Price:

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MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Human TNF receptor-associated factor 4

Cat.:

P15310Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human TNF receptor-associated factor 4

Cat.:

P15310Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human TNF receptor-associated factor 4

Protein for Human TNF receptor-associated factor 4

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17."
Tomasetto C.L. , Regnier C.H. , Moog-Lutz C. , Mattei M.-G. , Chenard M.-P. , Lidereau R. , Basset P. , Rio M.-C.
Genomics28:367-376(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT GLY-178
tissue: Mammary tumor.
2.

"TRAF4 expression in proliferating cells."
Miller H.G. , Pullen S.P. , White H.E. , Phipps R.P. , Kehry M.R. , Crute J.J.
Submitted (1998-08) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
tissue: Lung.
3.

Cai C.L. , Li R. , Wang R.S. , Miao S.Y. , Wang L.F.
Submitted (2005-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Cervix carcinoma.
4.

NIEHS SNPs program
Submitted (2005-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT THR-173
5.

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C. , Garber M. , Adams D.J. , Sharpe T. , Harrow J. , Lupski J.R. , Nicholson C. , Searle S.M. , Wilming L. , Young S.K. , Abouelleil A. , Allen N.R. , Bi W. , Bloom T. , Borowsky M.L. , Bugalter B.E. , Butler J. , Chang J.L. , more...
Nature440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Retinoblastoma.
7.

"Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma."
Regnier C.H. , Tomasetto C. , Moog-Lutz C. , Chenard M.-P. , Wendling C. , Basset P. , Rio M.-C.
J. Biol. Chem.270:25715-25721(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
8.

"TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues."
Krajewska M. , Krajewski S. , Zapata J.M. , VanArsdale T. , Gascoyne R.D. , Berern K. , McFadden D. , Shabaik A. , Hugh J. , Reynolds A. , Clevenger C.V. , Reed J.C.
Am. J. Pathol.152:1549-1561(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LTBR AND TNFRSDF16;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
9.

"TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction."
Ye X. , Mehlen P. , Rabizadeh S. , VanArsdale T. , Zhang H. , Shin H. , Wang J.J.L. , Leo E. , Zapata J.M. , Hauser C.A. , Reed J.C. , Bredesen D.E.
J. Biol. Chem.274:30202-30208(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TNFRSF16
10.

"Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase."
Xu Y.C. , Wu R.F. , Gu Y. , Yang Y.S. , Yang M.C. , Nwariaku F.E. , Terada L.S.
J. Biol. Chem.277:28051-28057(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH NCF1;SUBCELLULAR LOCATION
11.

"Tumor necrosis factor receptor-associated factor (TRAF) 4 is a new binding partner for the p70S6 serine/threonine kinase."
Fleckenstein D.S. , Dirks W.G. , Drexler H.G. , Quentmeier H.
Leuk. Res.27:687-694(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH RPS6KB1
12.

"TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF."
Takeshita F. , Ishii K.J. , Kobiyama K. , Kojima Y. , Coban C. , Sasaki S. , Ishii N. , Klinman D.M. , Okuda K. , Akira S. , Suzuki K.
Eur. J. Immunol.35:2477-2485(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH NCF1; TICAM1; IRAK1 AND TRAF6;INDUCTION
13.

"MEKK4 is an effector of the embryonic TRAF4 for JNK activation."
Abell A.N. , Johnson G.L.
J. Biol. Chem.280:35793-35796(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH MAP3K4
14.

"Subcellular targeting of oxidants during endothelial cell migration."
Wu R.F. , Xu Y.C. , Ma Z. , Nwariaku F.E. , Sarosi G.A. Jr. , Terada L.S.
J. Cell Biol.171:893-904(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TGFB1I1
15.

"TRAF4 is potently induced by TAp63 isoforms and localised according to differentiation in SCCHN."
Gu X. , Coates P.J. , MacCallum S.F. , Boldrup L. , Sjostrom B. , Nylander K.
Cancer Biol. Ther.6:1986-1990(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
16.

"Tumor necrosis factor receptor-associated factor 4 is a dynamic tight junction-related shuttle protein involved in epithelium homeostasis."
Kedinger V. , Alpy F. , Baguet A. , Polette M. , Stoll I. , Chenard M.P. , Tomasetto C. , Rio M.C.
PLoS ONE3:E3518-E3518(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
17.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-426;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
18.

"Ubiquitin ligase Smurf1 targets TRAF family proteins for ubiquitination and degradation."
Li S. , Lu K. , Wang J. , An L. , Yang G. , Chen H. , Cui Y. , Yin X. , Xie P. , Xing G. , He F. , Zhang L.
Mol. Cell. Biochem.338:11-17(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SMURF1;UBIQUITINATION
19.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-426;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
20.

"Solution structure of TRAF-type zinc finger domains from human TNF receptor-associated factor 4."
RIKEN structural genomics initiative (RSGI)
Submitted (2008-04) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 101-248

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